Join us!

03-17-2023 We are recruiting research specialists to join a NIH/BRAIN Initiative-funded project to define the anatomical, molecular, and functional diversity of neuronal subtypes in the cerebellum and determine how the dynamic neural activity of discrete cerebellar output circuits contributes to limb movement. 

Projects aim to: 1) define specific subtypes of neurons within the cerebellar nuclei by delineating their input and output connectivity and molecular identities, 2) establish the functional connectivity between distinct CN subpopulations and forelimb muscles and examines how cerebellar output pathways influence goal-directed forelimb movements, and 3) explore how the activity of discrete CN output pathways correlates with forelimb online correction and endpoint precision.

Principal Responsibilities:

Candidates will utilize molecular-genetic tools and techniques, such as cell-type specific Cre mouse lines, intersectional AAV and rabies transsynaptic viral tracing, and optogenetics, and combine this powerful circuit dissection with high-resolution behavioral assays, multielectrode neural recording, and electromyography (EMG) recording designed to probe the execution of dexterous limb movements. Additionally, candidates will use single nuclei RNA-sequencing approaches to clarify the molecular organization of cerebellar output circuits as distinguished by their distinct projection targets.

Preferred Qualifications:

B.S./M.S. in Neuroscience, Molecular Biology, Physiology or the equivalent. Seeking a candidate with a strong desire to develop an independent research project. Experience with molecular biology, anatomy/histology, electrophysiology, imaging, murine genetics, and/or murine behavioral analysis is considered valuable, but not essential. Please send CV and names of three references to info@chenlaboratory.us